Future Health - 11/21/25

Delivering care in the new virtual world… 

The Coming Age Of The “Digital Twin” If you haven’t heard of it, there’s a new concept that’s been introduced to the healthcare community, and you should become aware of it for future use. Specifically, it’s the creation of a digital twin or a virtual replica of a real-world patient, organ, device, or health system information that is continuously updated with real data. It combines information from medical records, imaging, sensors, and AI modeling to simulate how the real counterpart behaves, whether it's an institution or an individual, or anything in between. Some of the key applications include:

  • Patient twins: simulate individual health to guide personalized care,
  • Organ twins: model organs (like the heart, lungs, kidneys, etc.) for surgical or treatment planning and care optimization,
  • Hospital twins: related to optimizing staffing, workflow, and resource use within the institution; and,
  • Device twins: track and improve performance of implants or medical equipment.

The benefits of using “digital twins” are that it allows providers to offer more precise and personalized care with a reduction in overall risk and cost as well as improving the efficiency and effectiveness of the services provided through the use of an innovative tool set. There are challenges such as maintaining data privacy and security, the integration of complex and diverse data sets as well as minimal regulatory standards at the present time, along with minimal ethical frameworks in place to rely upon for deployment of these systems. However, with the ongoing need to reduce costs and enhance outcomes, the marketplace is beginning to increase its investments in the strategy in hopes of managing care delivery more effectively and more efficiently.

In particular, the Asia Pacific nations (e.g. Japan, China, Singapore) are seeing heavy investment in the idea as a precursor toward precision medicine and healthcare optimization. However, not to be outdone, heavy investments are also occurring in North America, which represents the fastest-growing market across the globe. Specifically, the research and development funding and technological leadership is emanating from three major players of IBM, Microsoft, and Siemens on the heels of major healthcare investments in telehealth use and big data integration. We all need to keep our eye on this one… 

The Distribution Of The Healthcare Dollar – I honestly forget where I saw a copy of this allocation of the healthcare dollar…but, wanted to pass it along. It reveals some of the disparate priorities of our healthcare expenditures as a nation…

dollar

The Impact Of Circadian Rhythm On Heart Health - Last month, the American Heart Association (AHA) released a report on the impact of circadian rhythms on cardiometabolic health. Specifically, the circadian rhythm is the body's internal 24-hour cycle that regulates our physical, mental, and behavioral changes, most notably the sleep-wake cycle or the "body clock” for individuals. Our cycle depends on the influence of external cues like light and darkness as well as hormonal release, appetite, and body temperature. Disruptions that occur in your cycles, derived from such issues as artificial light, irregular schedules, and late-night eating, can contribute to increased health risks for individuals, such as obesity, type 2 diabetes, hypertension, and cardiovascular disease. The AHA report focused on the importance of timing for sleep, meals, and exercise and offered up some specific suggestions. For example, one practical strategy is to engage in consistent sleep-wake times and morning sunlight exposure. Hmmm. Perhaps I’m failing on that front, although I have started to keep the shades down to prevent sunlight from sneaking into the bedroom too early. In addition, the report notes that an understanding of a patient’s chronotype (e.g., "morning larks" vs "night owls") who are then faced with sleep changes that go against their natural rhythm, can have negative consequences. Finally, the report noted that consideration of a patient’s circadian health should be included as part of ongoing patient evaluations. 

 

World & Future Health - 8/6/25

Delivering care in the evolving, interconnected, virtual world… 

I’ve altered the heading for this section to include the “World” along with “Future Health” as a segment in The Fickenscher Files. Why? Because I am of the firm belief that we are inextricably tied together – whether we want to be or not!! Going one step further, I believe it is important for us in sustaining the health of the world and people that live upon it to recognize and respect our interconnections – both intentional, logistical, political, and otherwise. So, I thought the modification in focus would be important as we move forward. I hope it is helpful…let me know as I’m sure many of you will!! 

An Opening Conversation – I was on my way home from a short trip to the post office when I had the opportunity to hear an interview of Omar Dajani and Mira Sucharov, two activists who are working to develop solutions to the Israeli-Palestinian conflict that started following the October 7, 2023, Hamas attack in Israel. They have been working to develop a framework for a viable two-state solution and have presented their ideas. This is worth listening to, so I encourage you to consider it. They both hold deep roots on both sides of the aisle – Omar as a Palestinian whose family goes back to the days of Napoleon and Mira, who lived as a young woman on a kibbutz in Israel, also with deep roots on the Israeli side. So, why do I raise this in my “health” of the world segment? Because I have come to the belief that we – as a people of Planet Earth – must learn to come together to solve problems. We have starvation in Palestine. We have all sorts of infestations in Africa that devastate the unserved, poor, and rural populations, we – as a world population – are contributing to global warming (yes, it is happening), and the list goes on. It seems that in recent years, we are headed to our respective corners. That does not bode well for the future of the world. Rather, we need to come together to solve these worldwide problems. My increasing fear is that I have lived through the “Golden Years” of evolving world health. Now, it seems we are heading back toward the Dark Ages. It’s disturbing… Dajani and Sucharov are completing a book entitled “View from the Vacant Lot.” I haven’t read it but I’m going to get it!!

Future Health - 8/14/23

Delivering care in the new virtual world… 

Will COVID Virus Detectors Become The Norm?  Researchers at Washington University at St. Louis have developed an innovative and cutting-edge technology that – I predict – will become the norm over the coming years. It is an “air monitor” that can detect the presence of the COVID virus in as little as 5 minutes with a very high degree of accuracy. The new technology is the outgrowth of a collaboration between the medical and engineering schools. The devices use an approach called a “wet cyclone” that samples the equivalent of 176 cubic feet of air in just 5 minutes. The simplicity is amazing. It simply goes from green to red if the virus is present in the air of the room! Even more exciting is the fact that the researchers are exploring how the device can be used for influenza, respiratory syncytial virus and other bugs. I predict that if these initial evaluations prove the value of the devices, we will see them on airplanes, in large auditoriums and other assorted gatherings where viruses are shared unbeknownst to the recipients. The proof of concept product is also small at only 1 foot wide and 10 inches tall. Imagine what a couple of years will do to the size of these devices. Is installing them on our mobile devices far down the road? Who knows? Technology marches on…

More Technology Innovation Contributed By AI/ML – The researchers at the Massachusetts Institute of Technology and McMaster University have collaborated to create a new antibiotic derived from artificial intelligence against a lethal drug-resistant bacterium, Acinetobacter baumannii which is most often associated with hospital acquired infections. I’m obviously a bit out-of-date since I had not heard of the bacterium. However, the World Health Organization (WHO) describes it as a “priority pathogen” because it can survive on surfaces for extended periods of time and acquire bacterial resistance from the acquired genes of other bacterial species. This is the good side of AI/ML at play and, it will no doubt become the norm in drug development among the pharmaceuticals in the coming months and years. We should expect more like this one in the not-too-distant future.

Future Health - 7/11/23

Future Health

Delivering care in the new virtual world…

 On The Verge Of Solving A Ubiquitous Problem – In following the evolution of artificial intelligence and machine learning, I came up a start-up that is quite intriguing - CancerVax. While the company is still as the pre-clinical stage it’s garnered the interest of heavy weight academic center UCLA. Together they are working on developing immunotherapy cancer treatments that mobilize the body’s immune system to fight cancer! The company is led by Ryan Davies who has served in a number of entrepreneurial start-ups – even while in college – in such areas of biotech, software, technology and e-commerce. He views the CancerVax initiative as the “Holy Grail” of cancer research. According to Bloomberg Business, the cancer immunotherapy market represents a potential growth of $196 billion by 2030. And, the expectations are not unwarranted. The immunotherapy market is already on the move with drugs like Opdivo (Bristol-Myers Squibb) and Keytruda (Merck) so there is clearly a pathway that has already been started down the immunotherapy road for cancer treatment initially with hopes that a prevention modality could be created down the road.

Future Health - 1/3/23

Delivering care in the new virtual world…

“Drag-and-Drop” Gene Editing On The Horizon – The whole process of gene editing just got a bit easier with a recent announcement by scientists at the Massachusetts Institute of Technology. They developed a new gene editing technology that can “drag-and-drop” large DNA sequences into the human genome. And, to top it off, they named the new tool PASTE which was recently described in the journal Nature Biotechnology. Oy vey!! This new technology will clearly accelerate the ability to develop and deploy new gene therapy approaches for underlying genomic problems and diseases. It eliminates the problems of the first generation CRISPR technology that used a bacterial enzyme to remove specific DNA known to cause disease by markedly reducing the chance of misappropriated mutations along with the second, third and other subsequent generations!! There are still issues but the long and short is that gene editing is getting better and better.

Mental Health Moves To The Forefront – Insurance plans for employees are moving toward better support for employee mental health and well-being as a workforce strategy. Why? Because it’s tied to enhanced job satisfaction as well as better physical health – all resulting in lower costs. payment models. The healthcare trends for 2023 are outlined in a report from the Busines Group on Health.

Mega-Mergers Harming Health Care – Check Out Lawton Burn’s new book on the impact of “mega-mergers” on healthcare delivery across the nation. It’s concerning…

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